Public transport in Prague is cheap and Plentiful. What's more is that it goes on throughout the night. Night trams have numbers in the 50s. One thing worth knowing is that all night trams go through Lazarska/Karlovo Namesti (Charles Square). So, if you know that tram 56 goes past your hotel you can jump on any night tram and change here to your required tram.
Lazarska/Karlovo Namesti (Charles Square)
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