Been here so many times and never get bored of it. There is a maze of narrow streets - during the day you can shop at little independent outlets, eat tapas, enjoy a beer in a little square or just wander. At night, add more bars and all sorts of weird places - last time I visited I found an ice-cream and chocolate waffle shop at 2am in the morning after a night at a great little club. For the full effect it's best to book your hotel in the Gothic Quarter. I used this site for a list of hotels.
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