Turkey
The best way to get to Pamukkale from Istanbul is by train. The Pamukkale Expresi, which has pullman seats, couchette and a sleeping car - depending on the level of luxury you need for the 15 hour journey - starts from HaydarPasa station in the Anatolian side of Istanbul and takes you to Denizli.
You can either book your seats online on the Turkish railways website (a bit of a maze) or book it from a TCDD authorised travel agent (it doesn’t cost any more). You could also combine it with a trip to Izmir and Ephesus.
You could get to Pamukkale by bus as well, in which case you go to the Otogar in istanbul and it is an 11 hour journey.
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