Some great places are to be found on/just off this street. For food you have the Maison des Gourmets and the Bistro, both in Castle Market, as well as the Port House for tapas.
For a good pint in a unique pub, check out Grogan's. An arty, down-at-heel pub frequented by those in the 25 - 85 age group, good conversation and a nice pint are guaranteed. If you're feeling peckish, they do ham and cheese toasties.
Another great pub is Peter's pub at the end of the road. Recently refurbished but thankfully left looking the same as always, only better! Great barmen.
For something a little more modern, try the South William. Three floors, funky music, cool people, great pies! It's a late bar too which means you can drink away until 2am or so.
From Dame Street, head up Georges Street and turn left just before Dunnes Stores. Then take the right at Butler's Chocolate Cafe.
From Grafton Street, go down Wicklow Street, at the side of Brown Thomas and turn left at Butlers Chocolate Cafe.
Sadly Maison des Gourmets has now closed down.