It connects most must-see places of interest: the atomic bomb museum and peace park, the main railway terminus, the waterfront and Dejima museum. At the waterfront there are many different restaurants and cafes. This is a good place to meet with the locals and share some Japanese whisky.
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Pay by coin as you leave the tram, or ask the driver for a "kaisuken" - a book of 11 tickets for 1000 yen.