To escape from the crowds in Sultanahmet and/or Taksim why not spend an evening (or two) on the Asian side of the city? Hop on a ferry from Eminonu, Karakoy or Besiktas and get off at Kadikoy.
For a great, quality meal of meze and grilled meat or fish head for the restaurants opposite the ferry terminal. Olympiat I and II are particularly good with muscle-bound waiters wobbling under trays piled high with a bewildering selection of hot and cold appetizers.
Only a short walk away (admittedly uphill) you can find a whole street of bars, full of the young, trendy and beautiful. Particular highlights are Isis (possibly Istanbul's only Egyptian theme bar) and Masal Evi (fairy house) a haven for couples.
When you're done, the hotels of Taksim are only a dolmus ride away, or taxi for the heavier of wallet.
Kadikoy - opposite the ferry terminal and then off Bahariye Caddesi
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