Main Street south of 49th avenue to about 55th is lined with shops selling wonderful Indian fabrics, foods and jewelery. Fabrics are beautiful, authentic and extremely reasonably priced, and the clothes are unique and beautiful.
Farther north on Main is also lovely, but quite different. Between about 33rd and 16th it has plenty of antique shops, second hand stores and cute little stores selling home furnishings and accessories (no chain stores). Between 16th and Seventh it's more eclectic, with some very good second-hand stores (the Salvation Army is on 12th just east of Main) and cafes. Urban Source, at 16th and Main, is a fantastic resource for craft supplies: they recycle industrial leftovers, and the results and the offerings are irresistable.
The strange triangle between Fraser, Main and Broadway is known as Dysfunction Junction, and hosts 2 outstanding second-hand bookstores, literary cafe Our Town, a pool hall, a neon art cafe, and several hole-in-the-wall galleries and restaurants. The Jem gallery is a particular gem; a recent exhibit featured the work of I.Braineater, an outstanding local artist.
Farther north again, Loomis arts and crafts superstore is an awesome place for paper junkies. Just to the west is the Seawall; you can go on the south side all the way to Kitsilano, or you can take the north side and go up to Yaletown, English Bay, and Stanley Park. If you know some tricks you can connect with Portside Road and skate all the way from Science World (near Loomis) to Stanley Park and back to the foot of Main street, a loop of about ten miles if you don't also skate around the park itself. And it's all on the Seawall, away from traffic, except for a mile along Portside Road.
North along Main is Chinatown, and then at the very foot of Main street is the Viaduct which will give you a fantastic view of the mountains, North Vancouver, and Downtown. It will also take you to Crab Park (closed after 10pm) which is the only beach on the Downtown Eastside, and features nesting eagles and hawks, seals in the water, and a marvelous break from city noise.
Nearby, on Alexander just west of Main is the Alibi Room, a very arty place with a very hot crowd, very good food, and very original (and tasty) cocktails. Open late, and for great Saturday brunch, but the DJ might be a bit loud if you're hungover. Not that I would know what that's like.
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