Everyone knows about the queues to get in and that even an early arrival doesn't seem to help - all of the groups are there too, apparently. If you want to avoid paying extra to cut down on the waiting time, simply wait until mid-afternoon before going. We went at about 3.30 and waited for about 20 minutes in a rapidly moving queue. The Sistine Chapel was still packed but it was worth it for the attendants who repeatedly "shshshed" everyone and boomed "Silence!" in a deep cross-teacher voice. The ceiling is worth the neck-straining.
St Peter's Square - follow the signs;
mv.vatican.va/3_EN/pages/MV_Home.html
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