There are two or three nightclubs in Siem Reap - this one tends to serve the locals more, and is less touristy. When you walk in (you may be frisked for knives) you'll be hit by the loud music (somewhat Western these days: Usher, Black Eyed Peas) and by the pictures of beer from the bar girls. Go for Angkor Beer. It is good, inexpensive. Now settle in and enjoy. Better still go with locals - these guys know how to party.
Just over the bridge from the old market area. A stroll. If in doubt catch a tuk tuk. Goes from 8:00pm to around 1:30am. (Remember, you'll be up at dawn to see Angkor, right?)
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