This is, I believe, the very best way of getting from the airport to your hotel and vice-versa.
The Shuttle (NOT to be confused with a number of recently arrived imitators with "similar' names" offers a truly excellent service that I have used many times when visiting Prague.
The drivers are all English speaking and a mine of local knowledge. Most importantly there is none of the "white knuckle" experience during the trip that colleagues have experienced with other services.
Is this your business?